Theory of Channel-Facilitated Metabolite Transport

Although the constructive role of attractive interactions between permeating particles and the channel has been appreciated for many years, a clear understanding and reliable quantitative description of the channel-facilitated metabolite transport are still incomplete. We use the language of the time-dependent particle propagator to describe channel-facilitated transport at the level of single-particle dynamics.

Related references:

A.M. Berezhkovskii and S.M. Bezrukov. Optimizing transport of metabolites through large channels: Molecular sieves with and without binding. Biophysical Journal, 2005, 88:L17-19. [PDF]

L. Dagdug, A.M. Berezhkovskii, S.M. Bezrukov, and G.H. Weiss. Diffusion-controlled reactions with a binding site hidden in the channel. Journal of Chemical Physics, 2003, 118:2367-2373. [PDF]

A.M. Berezhkovskii, M.A. Pustovoit, and S.M. Bezrukov. Channel-facilitated membrane transport: Average lifetimes in the channel. Journal of Chemical Physics, 2003, 119:3943-3951. [PDF]

A.M. Berezhkovskii, M.A. Pustovoit, and S.M. Bezrukov. Channel-facilitated membrane transport: Transit probability and interaction with the channel. Journal of Chemical Physics, 2002, 116:9952-9956. [PDF]

S.M. Bezrukov, A.M. Berezhkovskii, M.A. Pustovoit, and A. Szabo. Particle number fluctuations in a membrane channel. Journal of Chemical Physics, 2000, 113:8206-8211. [PDF]