Functional Consequences of Lipid Packing Stress
When two monolayers of a non-lamellar lipid are brought together to form a planar membrane, the resulting structure is under elastic stress. This stress changes the membrane’s physical properties and, by modifying the energetics of hydrophobic inclusions, influences conformational equilibria of membrane proteins.
Related references:
S.M. Bezrukov. Functional consequences of lipid packing stress. Current Opinion in Colloid and Interface Science, 2000, 5:237-243. [PDF]
S.M. Bezrukov, R.P. Rand, I. Vodyanoy, and V.A. Parsegian. Lipid packing stress and polypeptide aggregation: alamethicin channels probed by proton titration of lipid charge. Faraday Discussions, 1998, 111:173-183. [PDF]
S.L. Keller, S.M. Bezrukov, S.M. Gruner, M.W. Tate, I. Vodyanoy, and V.A. Parsegian. Probability of alamethicin conductance states varies with nonlamellar tendency of bilayer phospholipids. Biophysical Journal, 1993, 65:23-27. [PDF] |
